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These Creepy Mini-Brains May Finally Crack Deadly Brain Cancer

Brain organoids look like something between a malformed human brain and a character from Monsters, Inc.

But don’t be fooled by their grotesque appearance. Ever since their introduction three years ago, brain organoids—charmingly dubbed “mini-brains” and “brain balls”—have been a darling in neuroscience research.

Made from cells directly taken from human donors, these tiny clumps of cells roughly mimic how a human brain develops. Under a combination of growth chemicals and nurturing care, they expand to a few centimeters in diameter as their neurons extend their branches and hook up basic neural circuits.

Brain balls are as close as scientists can get to recreating brain development in a dish, where the process can be studied and tinkered with. To most neuroscientists, they could be the key to finally cracking what goes awry in autism, schizophrenia, and a myriad of other brain developmental disorders.

But when Dr. Howard Fine, an oncologist at Weill Cornell Medicine, first heard about these bizarre quasi-brains, development was the last thing on his mind.

What if, he thought, I’m looking at the solution to brain cancer?

Glioblastoma Terror

An oncologist studying glioblastoma, an especially aggressive type of brain cancer, Fine has treated over 20,000 patients in his 30 years at work.

“Almost all of them are dead,” he said recently to STAT news.

A diagnosis of glioblastoma—like AIDS in the 1980s—is essentially a delayed death sentence. Survival rate is a measly two percent three years after diagnosis. There are no effective drugs on the market. Every person’s brain cancer is its own amalgam of tumor cells. Like a mortal game of whack-a-mole, destroy one type, and the others can still spread and roam free.

Physicians have long thrown everything they’ve got at the aggressive cancer. Surgery, chemotherapy, radiation. Glioblastomas have little tentacles that cling onto normal brain tissue, and even surgically removing all the visible bits doesn’t work. In one extreme case, a surgeon excised the entire half brain that harbored the tumor—and the patient still died because the malignant cells had already invaded the other half of the brain.

The problem, according to Fine, is that oncologists have been pigeonholed.

Like most medical fields, scientists heavily rely on mouse models when studying glioblastoma.

How it usually works: a physician takes a sample of a patient’s brain tumor, expands the cells in a dish and transplants those resulting cells into a mouse. There, the hope is that the tumor cells will spring back into action, taking over the rodent’s brain as they had in the patient.

Unfortunately, this standard approach doesn’t really work. One of the reasons  glioblastomas are so insidious is that they contain tumor stem cells, which are notoriously hard to target with standard chemo—like a spark, they readily ignite the entire cancerous flame if even one escapes therapy.

As it happens, tumor stem cells are also tough to grow in the lab. So when scientists carefully prepare the cells to transplant into mice, they inadvertently miss one of the most crucial populations. The result is that glioblastomas are mysteriously tame after transplantation: they’re not nearly as aggressive as their original source.

In other words, scientists don’t really have a good way to study glioblastomas. Lacking a suitable model makes testing potential new drugs or other therapies extremely difficult. It’s no wonder that prospective treatments in mice hardly ever translate to successful clinical trials.

It’s oncology’s “dirty little open secret,” says Fine.

“My stance as an old man in this field is, someone has to start doing something different,” he says.

Quasi-Brains With Real Cancer

When Fine came upon the first report of brain organoids in 2013, he immediately perked up.

Could these quasi-human brains replace mice brains? he wondered.

After a few unsuccessful bouts with the brain organoid recipe—the first few batches took a wrong route towards quasi-pancreases and colons—he figured out the ingredients to make it work. In roughly six weeks, his team grew mini-brains roughly the same level of development as a 20-week-old human fetus.

Immediately, the brain organoids proved their worth.

When placed together with glioblastoma stem cells from patients in a dish, the cancer cells readily clamp onto the mini-brains. Within 24 hours, they begin driving their tentacles deeper into the brain-like tissue in a pattern “that looks 100 percent like what happens in the patient’s own brain,” says Fine.

What’s more, the brain-like environment of mini-brains revealed some strange properties of the cancer normally not detected in mice models.

Individual tumor cells seem to extend lengthy tubes that connect each other, much like an elaborate subway system. This network could be why these tumors are so good at resisting chemotherapy and radiation, says Fine.

It’s a strong lead: drugs that dismantle these networks already exist and could be tested in future studies against glioblastomas.

Me-Too Mini-Brains

Although Fine began making mini-brains using healthy cells, in the past few months he has turned his attention towards organoids grown from cancer patients.

Glioblastomas are known for their individualized “signatures”: each one harbors a slightly different soup of cells depending on the mutated DNA and signals from the environment.

Recapitulating the right combination of cells in the right percentages is exceedingly difficult—but because mini-brains mimic the patient’s own brain development, they offer a one-stop solution.

The plan is to “make hundreds of brain organoids for any given patient and use them to screen for drugs that can shrink that patient’s tumor,” he says.

According to STAT, earlier this year, Fine received approval to test out the strategy in one patient with advanced glioblastoma. His team created brain balls from her cells, added her tumor cells to give them cancer, then threw drug after drug onto the brain surrogates.

Unfortunately, the patient died before the team found a hit. But Fine still believes in his approach.

Glioblastoma patients are often too sick to withstand a drug screen. Even if, by some slight chance, a drug did magically work for a specific patient’s tumor, often there isn’t enough time for doctors to find that “unicorn” drug.

With hundreds of brain organoids simultaneously taking the brunt, that search may end a lot faster with a much happier outcome.

Last month, Fine received the prestigious National Institute of Health (NIH) Director’s Pioneer Award for his foray into cancerous mini-brains. With support in hand, Fine plans to further enhance the realism of their organoids by adding two bonus components: blood vessels, which support the health and growth of both normal brain cells and tumor cells, and immune cells that are an integral part of the brain’s natural defense system.

It’s high-risk, high-reward research; a “bold departure” from traditional ways; a paradigm shift in a long-stymied field.

“[This work] may lead to consequential scientific advances for our patients: new and more effective treatments and therapies,” says Fine. “I am deeply grateful for this opportunity.”

Image Credit: Glioblastoma brain cancer cells under microscope / Anna Durinikova /


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Empathy and Decision Making: Making Compassionate Decisions

“The biggest deficit that we have in our society and in the world right now is an empathy deficit. We are in great need of people being able to stand in somebody else’s shoes and see the world through their eyes.”

— Barack Obama

You don’t have to look hard to find quotes expounding the need for more empathy in society. As with Barack Obama’s quote above, we are encouraged to actively build empathy with others — especially those who are different from us. The implicit message in these pleas is that empathy will make us treat each other with more respect and caring and will help reduce violence. But is this true? Does empathy make us appreciate others, help us behave in moral ways, or help us make better decisions?

These are questions Paul Bloom tackles in his book Against Empathy: The Case for Rational Compassion. As the title suggests, Bloom’s book makes a case against empathy as an inherent force for good and takes a closer look at what empathy is (and is not), how empathy works in our brains, how empathy can lead to immoral outcomes despite our best intentions, and how we can improve our ability to have a positive impact by strengthening our intelligence, compassion, self-control, and ability to reason.

To explore these questions, we first need to define what we’re talking about.

What Is Empathy?

Empathy is an often-used word that can mean different things. Bloom quotes one team of empathy researchers who joke that “there are probably nearly as many definitions of empathy as people working on this topic.” For his part, Bloom defines empathy as “the act of coming to experience the world as you think someone else does.” This type of empathy was explored by philosophers of the Scottish Enlightenment. Bloom writes:

As Adam Smith put it, we have the capacity to think about another person and “place ourselves in his situation and become in some measure the same person with him, and thence form some idea of his sensations, and even feel something which, though weaker in degree, is not altogether unlike them.”

This is the definition and view of empathy that Bloom devotes most of the book to exploring. This is the “standing in another man’s shoes” type of empathy from Barack Obama’s quote above, which Bloom calls emotional empathy.

“I feel your pain” is more than a metaphor. It’s literal.

With emotional empathy, you actually experience a weaker degree of what somebody else feels. Researchers in recent years have been able to show that empathic responses of pain occur in the same area of the brain where real pain is experienced.

So “I feel your pain” isn’t just a gooey metaphor; it can be made neurologically literal: Other people’s pain really does activate the same brain area as your own pain, and more generally, there is neural evidence for a correspondence between self and other.

To make the shoe metaphor literal, imagine that you see somebody drop something heavy on their foot — you flinch because you know what this feels like and the parts of your brain that experience pain (the anterior insula and the cingulate cortex) react. You don’t feel the same degree of pain, of course — you didn’t drop anything on your foot after all — but it is likely that you have an involuntary physical reaction like a flinch, a facial grimace, or an audible outburst. This is an emotionally empathic response.

But there is another form of empathy that Bloom wants us to be aware of and consider differently. It relates to our ability to understand what is going on in the minds of others. Bloom refers to this form as cognitive empathy:

… if I understand that you are in pain without feeling it myself, this is what psychologists describe as social cognition, social intelligence, mind reading, theory of mind, or mentalizing. It’s also sometimes described as a form of empathy—“cognitive empathy” as opposed to “emotional empathy.”

In this sense, cognitive empathy speaks to our capacity to understand what is going on in the minds of others. In the case of pain, which is where a lot of empathy research is done, we’re not talking about feeling any degree of pain, as we might with emotional empathy, but instead, we simply understand that the other person is feeling pain without feeling it ourselves. Cognitive empathy goes beyond pain — our ability to understand what is going on in somebody else’s mind is an important part of being human and is necessary for us to relate to each other.

Empathy and compassion are synonyms in many dictionaries and used interchangeably by many, but they have different characteristics.

The brain is, of course, very complicated, so it is plausible that these two types of empathy could take place in the same part of the brain. So far, though, the research seems to indicate that they are largely separate:

In a review article, Jamil Zaki and Kevin Ochsner note that hundreds of studies now support a certain perspective on the mind, which they call “a tale of two systems.” One system involves sharing the experience of others, what we’ve called empathy; the other involves inferences about the mental states of others—mentalizing or mind reading. While they can both be active at once, and often are, they occupy different parts of the brain. For instance, the medial prefrontal cortex, just behind the forehead, is involved in mentalizing, while the anterior cingulate cortex, sitting right behind that, is involved in empathy.

The difference between cognitive and emotional empathy is important for understanding Bloom’s arguments. From Bloom’s perspective, cognitive empathy is “…a useful and necessary tool for anyone who wishes to be a good person—but it is morally neutral.” On the other hand, Bloom believes that emotional empathy is “morally corrosive,” and the bulk of his attack is directed at highlighting the pitfalls of relying on emotional empathy while making the case for cultivating and practicing “rational compassion” instead.

I believe that the capacity for emotional empathy, described as “sympathy” by philosophers such as Adam Smith and David Hume, often simply known as “empathy” and defended by so many scholars, theologians, educators, and politicians, is actually morally corrosive. If you are struggling with a moral decision and find yourself trying to feel someone else’s pain or pleasure, you should stop. This empathic engagement might give you some satisfaction, but it’s not how to improve things and can lead to bad decisions and bad outcomes. Much better to use reason and cost-benefit analysis, drawing on a more distanced compassion and kindness.

Here again, the definition of the terms is important for understanding the argument. Empathy and compassion are synonyms in many dictionaries and used interchangeably by many, but they have different characteristics. Bloom outlines the difference:

… compassion and concern are more diffuse than empathy. It is weird to talk about having empathy for the millions of victims of malaria, say, but perfectly normal to say that you are concerned about them or feel compassion for them. Also, compassion and concern don’t require mirroring of others’ feelings. If someone works to help the victims of torture and does so with energy and good cheer, it doesn’t seem right to say that as they do this, they are empathizing with the individuals they are helping. Better to say that they feel compassion for them.

Bloom references a review paper written by Tania Singer and Olga Klimecki to help make the distinction clear. Singer and Klimecki write:

In contrast to empathy, compassion does not mean sharing the suffering of the other: rather, it is characterized by feelings of warmth, concern and care for the other, as well as a strong motivation to improve the other’s well-being. Compassion is feeling for and not feeling with the other.

To summarize, emotional empathy could be simply described as “feeling what others feel,” cognitive empathy as “understanding what others feel,” and compassion as “caring about how others feel.”

Emotional empathy could be simply described as “feeling what others feel,” cognitive empathy as “understanding what others feel,” and compassion as “caring about how others feel.”

Empathy and Morality

Many people believe that our ability to empathize is the basis for morality because it causes us to consider our actions from another’s perspective. “Treat others as you would like to be treated” is the basic morality lesson repeated thousands of times to children all over the world.

In this way, empathy can lead us to rely on our self-centered nature. If this is true, Bloom suggests that the argument in its simplest form would go like this:

Everyone is naturally interested in him- or herself; we care most about our own pleasure and pain. It requires nothing special to yank one’s hand away from a flame or to reach for a glass of water when thirsty. But empathy makes the experiences of others salient and important—your pain becomes my pain, your thirst becomes my thirst, and so I rescue you from the fire or give you something to drink. Empathy guides us to treat others as we treat ourselves and hence expands our selfish concerns to encompass others.

In this way, the willful exercise of empathy can motivate kindness that would never have otherwise occurred. Empathy can make us care about a slave, or a homeless person, or someone in solitary confinement. It can put us into the mind of a gay teenager bullied by his peers, or a victim of rape. We can empathize with a member of a despised minority or someone suffering from religious persecution in a faraway land. All these experiences are alien to me, but through the exercise of empathy, I can, in some limited way, experience them myself, and this makes me a better person.

When we consider the plight of others by imagining ourselves in their situation, we experience an empathic response that can cause us to evaluate the morality of our actions.

When we consider the plight of others by imagining ourselves in their situation, we experience an empathic response that can cause us to evaluate the morality of our actions.

In an interview, Steven Pinker hypothesizes that it was an increase in empathy, made possible by the technology of the printing press and the resulting increase in literacy, that led to the Humanitarian Revolution during the Enlightenment. The increase in empathy brought about by our ability to read accounts of violent punishments like disembowelment and mutilation caused us to reconsider the morality of treating other human beings in such ways.

So in certain instances, empathy can play a role in motivating us to take moral action. But is an empathic response required to do so?

To use a classic example from philosophy—first thought up by the Chinese philosopher Mencius—imagine that you are walking by a lake and see a young child struggling in shallow water. If you can easily wade into the water and save her, you should do it. It would be wrong to keep walking.

What motivates this good act? It is possible, I suppose, that you might imagine what it feels like to be drowning, or anticipate what it would be like to be the child’s mother or father hearing that she drowned. Such empathic feelings could then motivate you to act. But that is hardly necessary. You don’t need empathy to realize that it’s wrong to let a child drown. Any normal person would just wade in and scoop up the child, without bothering with any of this empathic hoo-ha.

And so there has to be more to morality than empathy. Our decisions about what’s right and what’s wrong, and our motivations to act, have many sources. One’s morality can be rooted in a religious worldview or a philosophical one. It can be motivated by a more diffuse concern for the fates of others—something often described as concern or compassion…

I hope most people reading this would agree that failing to attempt to save a drowning child or supporting or perpetrating violent punishments like disembowelment would be at the very least morally reprehensible, if not outright evil.

But what motivates people to be “evil”? For researchers like Simon Baron-Cohen, evil is defined as “empathy erosion” — truly evil people lack the capacity to empathize, and it is this lack of empathy that causes them to act in evil ways. Bloom looks at the question of what causes people to be evil from a slightly different angle:

Indeed, some argue that the myth of pure evil gets things backward. That is, it’s not that certain cruel actions are committed because the perpetrators are self-consciously and deliberatively evil. Rather it is because they think they are doing good. They are fueled by a strong moral sense.

When the perpetrators of violence or cruelty believe that their actions are morally justified, what motivates them? Bloom suggests that it can be empathy. Empathy often causes us to choose sides, to choose whom to empathize with. We see this tendency play out in politics all the time.

Empathy often causes us to choose sides, to choose whom to empathize with.

Politicians representing one side believe they are saving the world, while representatives on the other side believe that their adversaries are out to destroy civilization as we know it. If I believe that I am protecting a person or group of people whom I choose to empathize with, then I may be motivated to act in a way I believe is morally justified, even though others may believe that I have harmed them.

Steven Pinker weighed in on this issue when he wrote the following in The Better Angels of our Nature:

If you added up all the homicides committed in pursuit of self-help justice, the casualties of religious and revolutionary wars, the people executed for victimless crimes and misdemeanors, and the targets of ideological genocides, they would surely outnumber the fatalities from amoral predation and conquest.

Bloom quotes Pinker and goes on to write:

Henry Adams put this in stronger terms, with regard to Robert E. Lee: “It’s always the good men who do the most harm in the world.”

This might seem perverse. How can good lead to evil? One thing to keep in mind here is that we are interested in beliefs and motivations, not what’s good in some objective sense. So the idea isn’t that evil is good; rather, it’s that evil is done by those who think they are doing good.

So from a moral perspective, empathy can lead us astray. We may believe we are doing good or that our actions are justified but this may not necessarily be true for all involved. This is especially troublesome when we consider how we are affected by a growing list of cognitive biases.

Empathy and Biases

While empathy may not be required to motivate us to save a drowning child, it can still help us consider the differing experiences or suffering of another person thus motivating us to consider things from their perspective or thus act to relieve their suffering:

I see the bullied teenager and might be tempted initially to join in with his tormenters, out of sadism or boredom or a desire to dominate or be popular, but then I empathize—I feel his pain, I feel what it’s like to be bullied—so I don’t add to his suffering. Maybe I even rise to his defense. Empathy is like a spotlight directing attention and aid to where it’s needed.

On the surface this seems like an excellent case for the positive power of empathy; it shines a “spotlight” on a person in need and motivates us to help them. But what happens when we dig a little deeper into this metaphor? Bloom writes

… spotlights have a narrow focus, and this is one problem with empathy. It does poorly in a world where there are many people in need and where the effects of one’s actions are diffuse, often delayed, and difficult to compute, a world in which an act that helps one person in the here and now can lead to greater suffering in the future.

He adds:

Further, spotlights only illuminate what they are pointed at, so empathy reflects our biases. Although we might intellectually believe that the suffering of our neighbor is just as awful as the suffering of someone living in another country, it’s far easier to empathize with those who are close to us, those who are similar to us, and those we see as more attractive or vulnerable and less scary. Intellectually, a white American might believe that a black person matters just as much as a white person, but he or she will typically find it a lot easier to empathize with the plight of the latter than the former. In this regard, empathy distorts our moral judgments in pretty much the same way that prejudice does.

We are all predisposed to care more deeply for those we are close to. From a purely biological perspective, we will care for and protect our children and families before the children or families of strangers. Our decision making often falls victim to narrow framing, and our actions are affected by biases like Liking/Loving and Disliking/Hating and our tendency to discount the pain of people we don’t like:

We are constituted to favor our friends and family over strangers, to care more about members of our own group than people from different, perhaps opposing, groups. This fact about human nature is inevitable given our evolutionary history. Any creature that didn’t have special sentiments toward those that shared its genes and helped it in the past would get its ass kicked from a Darwinian perspective; it would falter relative to competitors with more parochial natures. This bias to favor those close to us is general—it influences who we readily empathize with, but it also influences who we like, who we tend to care for, who we will affiliate with, who we will punish, and so on.

There are many causes for human biases — empathy is only one — but taking a step back, we can see how the intuitive gut responses motivated by emotional empathy can negatively affect our ability to make rational decisions.

Empathy’s narrow focus, specificity, and innumeracy mean that it’s always going to be influenced by what captures our attention, by racial preferences, and so on. It’s only when we escape from empathy and rely instead on the application of rules and principles or a calculation of costs and benefits that we can, to at least some extent, become fair and impartial.

While many of us are motivated to be good and to make good decisions, it isn’t always cut and dry. Our preferences for whom to help or which organizations to support are affected by our biases. If we’re not careful, empathy can affect our ability to see the potential impacts of our actions. However, considering these impacts takes much more than empathy and a desire to do good; it takes awareness of our biases and mental effort to combat their effects:

… doing actual good, instead of doing what feels good, requires dealing with complex issues and being mindful of exploitation from competing, sometimes malicious and greedy, interests. To do so, you need to step back and not fall into empathy traps. The conclusion is not that one shouldn’t give, but rather that one should give intelligently, with an eye toward consequences.

In addition to biases like Liking/Loving and Disliking/Hating, empathy can lead to biases related to the Representative Heuristic. Actions motivated by empathy often fail to take the broader picture into account; the spotlight doesn’t encourage us to consider base rates or sample size when we make our decisions. Instead, we are motivated by positive emotions for a specific individual or small group:

Empathy is limited as well in that it focuses on specific individuals. Its spotlight nature renders it innumerate and myopic: It doesn’t resonate properly to the effects of our actions on groups of people, and it is insensitive to statistical data and estimated costs and benefits.

Part of the challenge that exists with empathy is this innumeracy that Bloom describes. It is impossible for us to form genuine empathic connections with abstractions. Conversely, if we see the suffering of one, empathy can motivate us to help make it stop. As Mother Theresa said, “If I look at the mass, I will never act. If I look at the one, I will.” This is what psychologists call “the identifiable victim effect.”

While many of us are motivated to be good and to make good decisions, it isn’t always cut and dry.

Perhaps an example will help illustrate.  On October 17, 1987, 18-month-old Jessica McClure fell 22 feet down an eight-inch-diameter well in the backyard of her home in Midland, Texas. Over the next 2 ½ days, fire, police, and volunteer rescuers worked around the clock to save her. Media coverage of the emergency was broadcast all over the world resulting in Jessica McClure becoming internationally known as “Baby Jessica” and prompting then-President Ronald Reagan to proclaim that “…everybody in America became the godmothers and godfathers of Jessica while this was going on.” The intense coverage and global awareness led to an influx of donations, resulting in an $800,000 trust being established in Jessica’s name.

What prompted this massive outpouring of concern and support? There are millions of children in need every day all over the world. How many of the people who sent donations to Baby Jessica had ever tried to help these faceless children? In the case of Baby Jessica, they had an identifiable victim, and empathy motivated many of them to help Jessica and her family. They could imagine what it might feel like for those poor parents and they felt genuine concern for the child’s future; all the other needy children around the world were statistical abstractions. This ability to identify and put a face on the suffering child and their family enables us to experience an empathic response with them, but the random children and their families remain empathically out of reach.

None of this is to say that rescuers should not have worked to save Jessica McClure — she was a real-world example of Mencius’s proverbial drowning child — but there are situations every day where we choose to help individuals at the cost of the continued suffering of others. Our actions often have diffuse and unknowable impacts.

If our concern is driven by thoughts of the suffering of specific individuals, then it sets up a perverse situation in which the suffering of one can matter more than the suffering of a thousand.

Furthermore, not only are we more likely to empathize with the identifiable victim, our empathy has its limits in scale as well. If we hear that an individual in a faraway land is suffering, we may have an empathic response, but will that response be increased proportionally if we learned that thousands or millions of people suffered? Adam Smith got to the heart of this question in The Theory of Moral Sentiments when he wrote:

Let us suppose that the great empire of China, with all its myriads of inhabitants, was suddenly swallowed up by an earthquake, and let us consider how a man of humanity in Europe, who had no sort of connection with that part of the world, would be affected upon receiving intelligence of this dreadful calamity. He would, I imagine, first of all, express very strongly his sorrow for the misfortune of that unhappy people, he would make many melancholy reflections upon the precariousness of human life, and the vanity of all the labors of man, which could thus be annihilated in a moment. He would too, perhaps, if he was a man of speculation, enter into many reasonings concerning the effects which this disaster might produce upon the commerce of Europe, and the trade and business of the world in general. And when all this fine philosophy was over, when all these humane sentiments had been once fairly expressed, he would pursue his business or his pleasure, take his repose or his diversion, with the same ease and tranquility, as if no such accident had happened.

Empathy can inadvertently motivate us to act to save the one at the expense of the many. While the examples provided are by no means clear-cut issues, it is worth considering how the morality or goodness of our actions to help the few may have negative consequences for the many.

Charlie Munger has written and spoken about the Kantian Fairness Tendency, in which he suggests that for certain systems to be moral to the many, they must be unfair to the few.

For certain systems to be moral to the many, they must be unfair to the few.

Empathy and Reason

We are emotional creatures, then, but we are also rational beings, with the capacity for rational decision-making. We can override, deflect, and overrule our passions, and we often should do so. It’s not hard to see this for feelings like anger and hate—it’s clear that these can lead us astray, that we do better when they don’t rule us and when we are capable of circumventing them.

While we need kindness and compassion and we should strive to be good people making good decisions, we are not necessarily well served by empathy in this regard; emotional empathy’s negatives often outweigh its positives. Instead, we should rely on our capacity to reason and control our emotions. Empathy is not something that can be removed or ignored; it is a normal function of our brains after all, but we can and do combine reason with our natural instincts and intuitions:

The idea that human nature has two opposing facets—emotion versus reason, gut feelings versus careful, rational deliberation—is the oldest and most resilient psychological theory of all. It was there in Plato, and it is now the core of the textbook account of cognitive processes, which assumes a dichotomy between “hot” and “cold” mental processes, between an intuitive “System 1” and a deliberative “System 2.”

We know from Daniel Kahneman’s Thinking, Fast and Slow that these two systems are not inherently separate in practice. They are both functioning in our brains at the same time.

Some decisions are made faster due to heuristics and intuitions from experiences or our biology, while other decisions are made in a more deliberative and slow fashion using reason. Bloom writes:

We go through a mental process that is typically called “choice,” where we think about the consequences of our actions. There is nothing magical about this. The neural basis of mental life is fully compatible with the existence of conscious deliberation and rational thought—with neural systems that analyze different options, construct logical chains of argument, reason through examples and analogies, and respond to the anticipated consequences of actions.

We have an impulsive, emotional, and intuitive decision-making system in System 1 and a deliberative, reasoning, and (sometimes) rational decision-making system in System 2.

We will always have emotional reactions, but on average our decision making will be better served by improving our ability to reason rather than leveraging our ability to empathize

We will always have emotional reactions, but on average our decision making will be better served by improving our ability to reason rather than by leveraging our ability to empathize. One way to increase our ability to reason is to focus on improving our self-control:

Self-control can be seen as the purest embodiment of rationality in that it reflects the working of a brain system (embedded in the frontal lobe, the part of the brain that lies behind the forehead) that restrains our impulsive, irrational, or emotive desires.

While Bloom is unabashedly against empathy as an inherent force for good in the world, he is also a firm supporter of being and doing good. He believes that the “feeling with” nature of emotional empathy leads us to make biased and bad decisions despite our best intentions and that we should instead foster and encourage the “caring for” nature of compassion while combining it with our intelligence, self-control, and ability to reason:

… none of this is to deny the importance of traits such as compassion and kindness. We want to nurture these traits in our children and work to establish a culture that prizes and rewards them. But they are not enough. To make the world a better place, we would also want to bless people with more smarts and more self-control. These are central to leading a successful and happy life—and a good and moral one.


[Editor’s note: Where you see boldface in block quotes, emphasis has been added by Farnam Street.]

Sponsored by: Royce & Associates – Small Cap Specialists with Unparalleled Knowledge and Experience..


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Why Stephen Wolfram Decided to Livestream His Company’s Work

Stephen Wolfram explains his decision to show the world exactly how Wolfram Research works—via live stream.

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Why Intelligent Optimism Is Crucial to Human Progress

There is nothing to be gained from blind optimism. But an optimistic mindset can be grounded in rationality and evidence. It may be hard to believe, but we are living in the most exciting time in human history. Despite all of our ongoing global challenges, humanity has never been better off. Not only are we living healthier, happier, and safer lives than ever before, but new technological tools are also opening up a universe of opportunities.

In order to continue to launch moonshot ideas, tackle global challenges, and push humanity forward, it’s important to be intelligently optimistic about the future.

Our Pessimism Bias

When we think about the future of our species, many of us are inherently pessimistic. Our brains are wired to pay more attention to the threats in our personal lives and our world at large.

Many studies have shown we react more strongly to negative stimuli than positive stimuli, and that we dedicate more of our brain resources to negative information. Some psychologists have also shown that we tend to give greater weight to negative thoughts when making decisions and that we tend to remember negative events in our lives more than positives.

There is an evolutionary advantage to these tendencies. We often forget that our neural hardware has been developed to survive the African savannah, where survival depended on being aware of constant sources of danger. But it may no longer serve its purpose in our modern world.

The media is partially to blame for adding fuel to the fire. In fact, studies show that bad news outweighs good news by as much as seventeen negative news reports for every one good one. News agencies know very well that we will pay more attention to bad news and hence, “If it bleeds, it leads.”

Another team of psychologists from McGill revealed that people tend to choose to read articles with negative tones and respond much faster to headlines with negative words. You’re not constantly seeing negative headlines because the world is getting worse, you’re constantly seeing negative headlines because that’s what audiences react to.

Studies have shown that the public tends to pay most attention to news about war and terrorism and least about science and technology. Consequently, we have trained journalists and news channels to focus on those issues more than on our innovative breakthroughs. What does that say about us as a society?

A Need for Intelligent Optimism

Intelligent optimism is all about being excited about the future in an informed and rational way. The mindset is critical if we are to get everyone excited about the future by highlighting the rapid progress we have made and recognizing the tremendous potential humans have to find solutions to our problems.

Despite ongoing challenges, we have a lot to celebrate about how far we’ve come as a species. As optimists like Peter Diamandis point out, we are living in an era of abundance, and there’s a lot of evidence to prove it.

Let’s be very clear: being intelligently optimistic does not mean we turn our backs to the many global challenges we are faced with today. Our world is far from perfect. The refugee crisis, climate change, wealth inequality, and other global issues are significant and worthy of our attention.

But as physicist and futurist David Deutsch points out, “Problems exist; and problems are soluble with the right knowledge.” Intelligent optimism involves recognizing the many problems we are faced with and acknowledging that we can solve them just as we have overcome many other challenges in the past.

A Critical Mindset for Progress

We can’t let negative headlines and the media shape our perception of ourselves as a species, and the vision we have for the future. As legendary astronomer Carl Sagan said, “For all of our failings, despite our limitations and fallibility, we humans are capable of greatness.”

Hollywood likes to paint disproportionately dystopian visions of the world, and while those are possible futures, we can and must also imagine a future of humanity where we live in abundance, prosperity, and transcendence. We can’t expect current innovators and future generations to make this positive vision a reality if they believe our species is doomed for failure. It inspires us to continue to contribute to human progress and feel that we can push humanity forward.

It’s absolutely critical that our journalists cover the many challenges, threats, and issues in our world today. But just as we report the significant negative news in the world, we must also continue to highlight humanity’s accomplishments. After all, how can our youth grow up believing they can have a positive impact on the world if the news is suggesting otherwise?

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History Suggests the Hyperloop Is an Uncertain Promise for Future Cities

Proponents of Hyperloop have repeatedly suggested that their transportation technology will create new “mega-regions,” essentially reshaping the scope of cities. Multiple startups are now striving to defy critics and connect different dots on maps. But in the process they face formidable barriers and uncertain sociological outcomes.

Most recently, Richard Branson made a sizable investment in Hyperloop One, causing it to be rebranded as Virgin Hyperloop One. His investment helps legitimize the radical technology. This latest round of capital could allow the world to experience a new and distinctive transportation system. But will it transform cities in the ways being promised?

The idea for Hyperloop was first popularized in 2013, when Elon Musk published a white paper (PDF). Musk outlined a new method for expedited travel, characterizing it as “the right solution for the specific case of high traffic city pairs that are less than about 1500 km or 900 miles apart.” This solution entails shooting capsules of people and freight through near-vacuum steel tubes at speeds exceeding 700 miles per hour.

Governments all over the world have now signed exploratory agreements with Hyperloop companies. And if you’ll pardon the pun, hyperbolic claims have been made.

Tim Houter, CEO and founder of Hardt Global Mobility, stated, “[Hyperloop] will make you able to travel over this whole continent, as you can now travel with a metro in a city.” His company’s website calls on people to imagine “a world without traffic jams, without schedules or rush, a world where you can live and work at any place you desire, a world where distance does not matter.”

Alan James, VP of worldwide business development at Hyperloop One, has suggested, “If you connect two cities with Hyperloop, you get, effectively, a sort of global city punching above its weight in a global economy.”

If built, it’s unclear how these systems would actually impact society. In spite of this ambiguity, public presentations about Hyperloop are consistently grandiose. A Hyperloop One blog post authored by strategic communications manager Leslie Horwitz suggested that the new technology could “stimulate growth and bring much-needed economic balance to the UK.”

Hyperloop pods would theoretically allow workers to commute over vast distances, connecting them with previously inaccessible jobs. “Through fast and seamless connections, a Hyperloop system would distribute the massive economic pull of London more equally and more productively,” states Horwitz’s blog post.

However, the cost of a ticket and the system’s reliability are looming question marks. Even occasional technical glitches would pose a significant impediment to the daily commuter. Additionally, “the massive economic pull of London” has not been distributed “more equally and more productively” within London itself, as was graphically demonstrated by the 2011 England riots and the Grenfell Tower fire.

Bridging Social and Economic Divides

It makes sense that Hyperloop companies are framing their product’s value in grandiose societal terms, given that the stakeholders are involved in governance and are more interested in public policy than linear electrical motors. However, some of the PR materials make even bolder claims than the UK post.

A recent blog post was titled “How Hyperloop Could Transform Mexico’s Megaregion.” The post alleged that “a high-speed intercity link could alter the economic calculus of central Mexico: employers in Guadalajara could access job seekers in León, and industry knowledge created in Mexico City could spill into firms across the four cities. Municipal governments, charged with governing a more connected region, could pursue coordinated infrastructure plans.”

These projections also seem unsubstantiated. The cost of a ticket has yet to be determined. Industry knowledge can already “spill into firms across the four cities” via the internet. And it’s hard to imagine a near-vacuum steel tube redeeming economies and governments that are presently embroiled in corruption and cartel violence.

Infrastructure investments don’t always yield the expected social dividends. China’s bullet trains were initially promoted as forward-thinking and a means of putting migrant workers within reach of jobs. For many, China’s high-speed rail now serves as a painful reminder of debt burden, the growing wealth gap, and the corrupt ministers and contractors involved. The high-speed trains are used almost exclusively by wealthy businessmen. The working poor simply can’t afford the higher ticket prices and instead travel on long-distance buses.

A high-speed train may save everyone the same amount of time, but different peoples’ time is valued differently. For a low-paid worker, the arithmetic doesn’t make sense. An extra dollar is better than an extra hour. A report from the World Bank notes “the overall financial performance of high-speed train services broadly depends on enough people being able to pay a premium to use them.”

Paradigm Shifts

Academics have long studied the effects of human geography, and have observed dramatic and unpredictable paradigm shifts. In the 1950s, city planners used hyperbole when they suggested that highways could act as a panacea, unclogging the arteries of unhealthy cities. Many of these federally-funded highway projects decimated African-American communities. Automobiles and highways led to suburbanization and urban decline. If Hyperloop technology does indeed transform the very meaning of a city, could there be negative consequences?

When asked to comment on these implications, Timothy McGettigan, a Fulbright Scholar and professor of sociology, replied, “Such Hyperloops give new meaning to the notion of white flight. Beginning with freeway bypasses, wealthy white folks have been engineering forms of transport that augment their privilege and minimize contact with pigmented ruffians. The privileged are always looking for ways to live the good life while minimizing contact with folks who make them feel guilty.”

He added, “Believe it or not, I am a big supporter of science and technology. It irks me, however, that we spend untold trillions on chasing stars, while hungry kids must fight over crumbs.”

The Mid-Ohio Regional Planning Commission proposed a Hyperloop that would connect Chicago to Columbus to Pittsburgh. When asked about this “Midwest Connect” proposal, Earl Smith, Rubin Distinguished Professor of American Ethnic Studies at Wake Forest University, observed that there are many unknowns.

“We don’t know about the development of ghettos because we don’t know what’s on each end. We don’t know the race/ethnicity of those leaving Chicago for Pittsburgh nor do we have a good hold on just what exists in Pittsburgh,” he wrote in an email to this reporter. “Who is the target audience leaving Chicago? What types of jobs are in Pittsburgh: Tech industry? Blue collar laborers? White collar business jobs? Finally, does this proposal bring any meaningful economic development to the city of Chicago? I doubt it.”

Proponents of Hyperloop have often noted that railways ushered in the global industrial revolution. They claim that Hyperloop now offers similar potential.

Risto Penttilä, CEO, Finland Chamber of Commerce, opined, “In the 19th century, railways created nations and trading areas in North America and Europe. In the 21st century, the new regional catalyst could be rapid transport. Instead of tweaking NAFTA, the new US administration should be building high-speed transport systems that would connect Canadian and US cities.”

In an introduction to the book, Canadian National Railways, Vol. 1: Sixty Years of Trial and Error, S.W. Fairweather characterized the railway as a tool through which nations were forged. “No wonder railways became an obsession. No wonder that any and all means were used to obtain capital to build them and that speculative enthusiasm passed the bounds of reason,” he wrote. “The errors arising from too enthusiastic speculation, though disastrous to investors in railway securities, did not greatly lessen the usefulness of railways to the country.” Although these words were written many decades ago, they could be considered a warning for Hyperloop investors in our modern times.

Large amounts of investment capital have already been poured into Hyperloop startups. Hyperloop One received a significant investment from DP World Group of Dubai. Their total funding is now $245 million. In 2016, a rival company, Hyperloop Transportation Technologies, also claimed to have secured over $100 million in investments, but that total included an approximation of volunteered man-hours.

Megaprojects are difficult to plan and predict. A 2014 paper from Oxford University’s Bent Flyvbjerg noted that nine out of ten megaprojects have cost overruns, due to a variety of factors such as long planning horizons, inadequate contingencies, optimism bias, and over-commitment to project concepts at an early stage.

It is apparent that transportation can significantly impact the way people live. However,  society is complex, consistently defying the expectations of central planners and corporate visionaries. Despite Hyperloop’s potential, it’s currently impossible to know how it will truly impact our cities, societies, and lives.

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Apple Executive Reveals More of Its Self-Driving Technology

In a talk at a conference, Apple’s head of artificial-intelligence research discussed projects for navigation and mapping that would be useful for self-driving cars.

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